EXPLORATION OF COLLABORATIVE DESIGN SPACES: ENGINEERING INTERACTIONS AND WORKFLOWS IN PRODUCT DEVELOPMENT

Product Lifecycle Management (PLM) initiatives can improve an enterprise’s efficiency by increasing collaborative design opportunities within its business structure. PLM solutions provide digital mediums to collaborate on all aspects of a company’s workflow, including engineering, testing, manufacturing, marketing, business, and field support services. This paper examines the major PLM tools and software used to establish a collaborative engineering design space; computer-aided design (CAD), computer-aided engineering (CAE), computer-aided manufacturing (CAM), and product data management (PDM). The interactions between these PLM tools and a design team’s organizational structure are analyzed to determine some of the most effective PLM integration strategies to improve collaboration for all business functions. Engineering enterprises may split their work functions into technical and non-technical categories and match them with PLM solutions to create a collaborative design space that integrates all departments. A case study presents a university design team whose objective was collaborative creation of a digital twin for a scale tracked vehicle. The Siemens Teamcenter software tool was integrated within the team’s design procedures to improve the process. The results of integrating advanced PDM software into their workflow, including troubleshooting issues and problems, were explored in this paper. PDM and workflow interactions throughout the case study produced many unique outcomes that require additional PLM engineering solutions. Overall, advanced PDM software increased collaboration and efficiency of their design process

A competitive enzyme immunoassay for the quantitative detection of cocaine from banknotes and latent fingermarks

A sensitive and versatile competitive enzyme immunoassay (cEIA) has been developed for the quantitative detection of cocaine in complex forensic samples. Polyclonal anti-cocaine antibody was purified from serum and deposited onto microtiter plates. The concentration of the cocaine antibody adsorbed onto the plates, and the dilution of the cocaine-HRP hapten were both studied to achieve an optimised immunoassay. The method was successfully used to quantify cocaine in extracts taken from both paper currency and latent fingermarks. The limit of detection (LOD) of 0.162 ng mL-1 achieved with the assay compares favourably to that of conventional chromatography-mass spectroscopy techniques, with an appropriate sensitivity for the quantification of cocaine at the low concentrations present in some forensic samples. The cEIA was directly compared to LC-MS for the analysis of ten UK banknote samples. The results obtained from both techniques were statistically similar, suggesting that the immunoassay was unaffected by cross-reactivity with potentially interfering compounds. The cEIA was used also for the detection of cocaine in extracts from latent fingermarks. The results obtained were compared to the cocaine concentrations detected in oral fluid sampled from the same individual. Using the cEIA, we have shown, for the first time, that endogeneously excreted cocaine can be detected and quantified from a single latent fingermark. Additionally, it has been shown that the presence of cocaine, at similar concentrations, in more than one latent fingermark from the same individual can be linked with those concentrations found in oral fluid. These results show that detection of drugs in latent fingermarks could directly indicate whether an individual has consumed the drug. The specificity and feasibility of measuring low concentrations of cocaine in complex forensic samples demonstrates the effectiveness and robustness of the assay. The immunoassay presents a simple and cost-effective alternative to the current mass spectrometry based techniques for the quantitation of cocaine at forensically significant concentrations

The future-climate, current-policy framework: towards an approach linking climate science to sector policy development

That global climate is being altered by human activities is well-established; for specific locations, however, the details of how and when many aspects of the changes will become manifest remains somewhat uncertain. For many policy makers there is a gap between recognising a long-term change and implementing short-term practical responses; therefore many countries are failing to implement changes needed for long-term adaptation. Traditional planning approaches are often closely aligned with near- term political cycles and perform poorly in terms of prioritising interventions that address multi-decadal climate impacts. We propose a novel approach that builds on adaptive planning and lessons from the business sector. The Future-Climate, Current-Policy (FCCP) Framework is based on plausible medium-term future climate scenarios, linked 'backwards' to identify short-term 'no regrets' actions. The approach was designed by a team of climate scientists and policy practitioners in East Africa and tested in national and regional fora. Initial trials of the FCCP Framework has proved it to be popular and effective as a way of linking climate science with policy. Its use shows promise as a way of initiating discussions that can enable long-term climate change information to feed effectively into the policy and planning process

Resume of Charles Frederick Rowell, 1972

Naval Postgraduate School Faculty Resum

Some technical and economic concerns relating to shipboard pollution abatement

Three questions related to abatement of pollution from Naval vessels are examined. Current candidates for shipboard sewage treatment application are discussed with respect to limitations of development imposed by technical processes utilized. Limited flush with incineration and biological treatment are judged ready for application with the latter method less desirable for several secondary reasons. Wet air oxidation is also considered a good candidate. Open ocean impact of oil and sewage discharge is the second area examined. The third discussion involves an examination of the economic factors related to contract sewage treatment shows that it is most probable that the Navy can work with municipal authorities to their mutual advantages. Reasonable amounts of salt water do not reduce efficiency of biological plants of the aerobic varietysupported by: Naval Ship Systems Command Project Order No. 55403http://archive.org/details/sometechnicaleco00row

Separation of fingerprint constituents using magnetic silica nanoparticles and direct on-particle SALDI-TOF-mass spectrometry

Two types of amorphous, silica nanoparticles have been produced and used as surface assisting agents during laser desorption/ionisation time-of flight-mass spectrometry (SALDI-TOF-MS). The first is hydrophilic possessing surface aminopropyl groups and the second hydrophobic containing surface phenyl groups. Each particle type acts as a solid phase adsorbent, adsorbing analytes according to their charge and hydrophobicity. The adsorbed analytes can be directly analysed on the particles using SALDI-TOF-MS. Intrinsically magnetisable versions of the hydrophobic particles act as magnetic solid phase extraction (MSPE) materials which are used to selectively adsorb analytes within a mixture deposited onto a surface, transfer the adsorbed components using a magnetic wand and to deposit the particles at a site adjacent to that of the original mixture. Non-adsorbed components remain at the original site. The extracted and residual analytes are then directly analysed on the surface by SALDI-TOF-MS. Using fingerprints as an example of a complex biological matrix, this new approach has been used to separate polar (amino acids) and non-polar constituents (squalene and fatty acids) within latent fingerprints deposited on a surface and for their subsequent direct analysis on the surface by SALDI-TOF-MS. Alanine, ornithine, lysine and aspartic acid which were undetected or poorly detected prior to separation showed improved signal detection after separation.Accepted versio

Doped amorphous silica nanoparticles as enhancing agents for surface-assisted time-of-flight mass spectrometry

This article examines the use of doped amorphous silica nanoparticles for surface-assisted laser desorption/ionisation-time of flight-mass spectrometry (SALDI-TOF-MS) of hydrophilic and hydrophobic compounds. A range of particles with surface aliphatic carboxylic, aminophenyl, phenyl or aminopropyl groups have been produced and these have been doped with carbon black, polyaniline or graphite. The effects of surface groups and dopants on the laser desorption/ionisation process were studied. The key factor in effective LDI was the presence of carbon black dopant carrying carboxyphenyl or phenyl residues for positive and negative ion formation. The second key factor was the presence of hydrophilic surface functional groups for hydrophilic amino acid analytes for their detection in positive or negative mode as protonated or de-protonated species respectively whereas hydrophobic surfaces were need for ionisation via cationisation for the hydrophobic analyte squalene. The mechanism for LDI of these particles appears to involve initial adsorption of the analyte onto the surface of the particle, formation of primary ions via adsorption of laser UV irradiation by carboxyphenyl residues attached to the carbon black network which act in an equivalent way to the matrix in matrix-assisted LDI. This is followed by reaction of the primary ions with neighbouring adsorbed analyte molecules. The latter are then released possibly via thermal desorption following proton donation or acceptance from/to via surface residues such carboxylate groups associated with the carbon black within the dopant. Alternatively in the absence of such proton donor/acceptor residues as with hydrophobic particles, the primary ions are released from the particles during desorption and form cation adducts as sodiated and potassiated species in the gas phase above the surface.Accepted versio